Interleukin-6 receptor

Interleukin-6 receptor (IL-6R) is a type of protein that in humans is encoded by the IL6R gene. It is a component of the immune system and plays a crucial role in inflammation and immune response.

Structure

The IL-6R protein is a type I cytokine receptor, which is characterized by the presence of a transmembrane domain. It is composed of two subunits: an alpha chain (IL-6Rα) and a beta chain (gp130). The alpha chain is responsible for ligand binding, while the beta chain is involved in signal transduction.

Function

The primary function of the IL-6R is to mediate the effects of interleukin-6 (IL-6), a cytokine that plays a central role in immune response, inflammation, and hematopoiesis. When IL-6 binds to the IL-6R, it triggers a cascade of intracellular signaling events that ultimately lead to the activation of various immune cells.

Clinical significance

Alterations in the IL-6/IL-6R signaling pathway have been implicated in a variety of diseases, including rheumatoid arthritis, systemic lupus erythematosus, and cancer. In addition, therapeutic strategies targeting the IL-6/IL-6R pathway are currently being explored for the treatment of these and other diseases.

See also

• Interleukin-6
• Cytokine receptor
• Immune system
• Inflammation

References

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