Interleukin-7
Interleukin-7 (IL-7) is a protein and a cytokine that plays a crucial role in the immune system. It is produced by stromal cells in the bone marrow and thymus, and its primary role is to stimulate the development of T cells and B cells from stem cells.
Function[edit | edit source]
IL-7 is essential for lymphocyte development. It promotes the survival and proliferation of pre-B and pro-B cells, as well as immature and mature T cells. IL-7 also enhances the function of mature T cells and can influence the balance between regulatory T cells and effector T cells.
Clinical significance[edit | edit source]
Due to its role in immune cell development and function, IL-7 has been implicated in several immune disorders, including autoimmune diseases, immunodeficiency disorders, and cancer. Therapies that target IL-7 or its receptor are currently being investigated for the treatment of these conditions.
Autoimmune diseases[edit | edit source]
In autoimmune diseases, the immune system mistakenly attacks the body's own cells. Studies have shown that levels of IL-7 can be elevated in certain autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. This suggests that IL-7 may contribute to the pathogenesis of these diseases by promoting the survival and function of autoreactive T cells.
Immunodeficiency disorders[edit | edit source]
In immunodeficiency disorders, the immune system is not able to mount an effective response to infections. IL-7 therapy has been proposed as a potential treatment for these conditions, as it can stimulate the development and function of immune cells.
Cancer[edit | edit source]
IL-7 has also been implicated in cancer, as it can promote the survival and proliferation of cancer cells. Therapies that block the action of IL-7 or its receptor are currently being investigated for the treatment of various types of cancer.
See also[edit | edit source]
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