Interleukin 12 receptor
Interleukin 12 receptor - human high affinity interleukin 12 receptor beta (type I cytokine receptor 2 family) is composed of interleukin 12 receptor beta 1 chain (il12rb1 gene) and interleukin 12 receptor beta 2 chain (il12rb2 gene), both type I transmembrane proteins involved in signal transduction and each containing 5 fniii domains; a box 1 motif required for jak interaction/activation; and a wsxws motif for protein folding, intracellular transport, and cell surface receptor binding. Il12rb1/2 activity appears to contribute to host defense mechanisms and the inflammatory response. Both il12rb1 oligomers and il12rb2 oligomers act as a low affinity il12 receptor.
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