Interleukin 12 receptor, beta 1 subunit
Interleukin 12 receptor, beta 1 subunit (IL12RB1) is a type of protein that in humans is encoded by the IL12RB1 gene. This protein is a subunit of the interleukin 12 (IL-12) receptor complex. The IL-12 receptor is a heterodimeric receptor formed by IL12RB1 and IL12RB2.
Function[edit | edit source]
The IL12RB1 protein is expressed on T cells, natural killer cells, and dendritic cells. It is involved in IL-12-mediated signaling pathway and is important for the differentiation of Th1 cells, a type of T helper cell. IL12RB1 is also involved in enhancing the cytotoxic activity of natural killer cells and promoting the production of IFN-gamma by T cells and natural killer cells.
Clinical significance[edit | edit source]
Mutations in the IL12RB1 gene can lead to IL12RB1 deficiency, a primary immunodeficiency disorder. This condition is characterized by increased susceptibility to infections caused by mycobacterium, including tuberculosis and BCG vaccine complications. IL12RB1 deficiency is inherited in an autosomal recessive manner.
See also[edit | edit source]
- Interleukin 12
- Interleukin 12 receptor, beta 2 subunit
- T lymphocyte
- Natural killer cell
- Dendritic cell
- Th1 cell
- Interferon gamma
- IL12RB1 deficiency
- Mycobacterium tuberculosis
- Bacille Calmette-Guérin
References[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
