Interleukin 17f

Interleukin 17F (IL-17F) is a cytokine that is part of the interleukin 17 family, which plays a crucial role in inflammation and the immune response. IL-17F is produced by a variety of immune cells, including T helper 17 cells (Th17), and is involved in the pathogenesis of several autoimmune diseases.

Structure

IL-17F is a protein that forms a homodimer, meaning it consists of two identical subunits. The structure of IL-17F is similar to that of other members of the IL-17 family, characterized by a cystine-knot fold. The gene encoding IL-17F is located on chromosome 6 in humans.

Function

IL-17F is primarily involved in the induction of pro-inflammatory cytokines and chemokines. It acts on a variety of cell types, including epithelial cells, endothelial cells, and fibroblasts, to promote the expression of cytokines such as IL-6, IL-8, and G-CSF. This cytokine is also involved in the recruitment of neutrophils to sites of inflammation.

Role in Disease

IL-17F has been implicated in the pathogenesis of several autoimmune diseases, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Elevated levels of IL-17F have been observed in the synovial fluid of patients with rheumatoid arthritis and in the lesions of patients with psoriasis.

Psoriasis

In psoriasis, IL-17F contributes to the hyperproliferation of keratinocytes and the recruitment of inflammatory cells to the skin. Therapies targeting IL-17F, such as biologics that inhibit IL-17F activity, have shown efficacy in reducing the symptoms of psoriasis.

Rheumatoid Arthritis

In rheumatoid arthritis, IL-17F is involved in the inflammation and destruction of joint tissue. It promotes the production of matrix metalloproteinases and other enzymes that degrade cartilage and bone.

Inflammatory Bowel Disease

In inflammatory bowel disease, IL-17F contributes to the chronic inflammation of the gastrointestinal tract. It is involved in the recruitment of neutrophils and the production of pro-inflammatory cytokines in the intestinal mucosa.

Therapeutic Target

Due to its role in inflammation and autoimmune diseases, IL-17F is a target for therapeutic intervention. Monoclonal antibodies that neutralize IL-17F or its receptor have been developed and are used in the treatment of conditions such as psoriasis and ankylosing spondylitis.

See Also

• Interleukin 17 family
• Cytokine
• Autoimmune disease

External Links

• UniProt entry for IL-17F
• NCBI Gene entry for IL-17F