Interleukin 28B

Interleukin 28B (also known as IL28B) is a protein that in humans is encoded by the IL28B gene. It is a member of the interferon family, which are proteins released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells.

Function

IL28B is involved in immune responses and plays a crucial role in the defense against viral infections. It has antiviral activity and is capable of up-regulating MHC class I molecules, enhancing the presentation of viral antigens to T cells.

Clinical significance

Variations in the IL28B gene are associated with different outcomes in diseases such as hepatitis C and HIV. Certain IL28B genotypes are linked to a higher likelihood of spontaneous clearance of hepatitis C virus, as well as a better response to treatment for both hepatitis C and HIV.

See also

• Interleukin
• Interferon
• Hepatitis C
• HIV