Interleukin 28B
Interleukin 28B (also known as IL28B) is a protein that in humans is encoded by the IL28B gene. It is a member of the interferon family, which are proteins released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells.
Function[edit | edit source]
IL28B is involved in immune responses and plays a crucial role in the defense against viral infections. It has antiviral activity and is capable of up-regulating MHC class I molecules, enhancing the presentation of viral antigens to T cells.
Clinical significance[edit | edit source]
Variations in the IL28B gene are associated with different outcomes in diseases such as hepatitis C and HIV. Certain IL28B genotypes are linked to a higher likelihood of spontaneous clearance of hepatitis C virus, as well as a better response to treatment for both hepatitis C and HIV.
See also[edit | edit source]
References[edit | edit source]
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