Interleukin 8 receptor, beta

Interleukin 8 receptor, beta
Identifiers
Symbol	CXCR2
Alt. symbols	IL8RB, CD182
NCBI gene	3579
HGNC	6025
OMIM	146929
RefSeq	NM_001557
UniProt	P25025
Other data
Locus	Chr. 2 q35
Search for Structures Swiss-model Domains InterPro

Interleukin 8 receptor, beta (IL8RB), also known as CXCR2 or CD182, is a protein that in humans is encoded by the CXCR2 gene located on chromosome 2q35. This receptor is a member of the CXC chemokine receptor family and plays a critical role in the function of the immune system, particularly in the process of inflammation and chemotaxis.

Function

The IL8RB receptor is primarily involved in the regulation of neutrophil migration and degranulation. It is a specific receptor for the chemokine Interleukin 8, which is a major mediator of inflammatory responses. Upon binding to IL-8, the IL8RB receptor triggers a cascade of events that promote the migration of neutrophils to the site of infection or injury, where they can perform their role in immune defense.

Structure

The IL8RB receptor is a G protein-coupled receptor (GPCR), which spans the cell membrane seven times. It is activated by binding to its ligand, IL-8, which induces a conformational change in the receptor, leading to the activation of various intracellular signaling pathways.

Clinical Significance

Alterations in the expression or function of IL8RB can lead to various inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and various types of cancer. As such, it is considered a potential target for therapeutic interventions aimed at modulating the immune response and inflammation.

See also

• Interleukin 8
• CXC chemokine receptors
• Chemokine receptors