Intussusceptive angiogenesis

Intussusceptive angiogenesis is a process of blood vessel formation that occurs by splitting of an existing vessel. This process is also known as splitting angiogenesis or non-sprouting angiogenesis. It is one of the two ways in which angiogenesis can occur, the other being sprouting angiogenesis.

Overview

Intussusceptive angiogenesis is a process that involves the splitting of a pre-existing blood vessel into two new vessels. This process is different from sprouting angiogenesis, which involves the growth of new blood vessels from pre-existing ones. Intussusceptive angiogenesis is a faster process than sprouting angiogenesis and is thought to play a role in the normal growth and development of the vascular system, as well as in the growth of tumors.

Process

The process of intussusceptive angiogenesis begins with the formation of a transluminal tissue pillar within the lumen of a pre-existing blood vessel. This pillar is formed by the fusion of the opposing endothelial cells lining the vessel. The pillar then expands and splits the vessel into two new vessels. This process is regulated by various growth factors and cytokines, including vascular endothelial growth factor (VEGF) and angiopoietin.

Role in Disease

Intussusceptive angiogenesis is thought to play a role in the growth of tumors. Tumors require a blood supply to grow, and they can obtain this supply through the process of angiogenesis. Intussusceptive angiogenesis is a faster process than sprouting angiogenesis, making it a potentially important mechanism for tumor growth. In addition, intussusceptive angiogenesis has been implicated in other diseases, such as pulmonary hypertension and retinopathy.

Research

Research into intussusceptive angiogenesis is ongoing, with the aim of developing new treatments for diseases such as cancer. By understanding the mechanisms of intussusceptive angiogenesis, it may be possible to develop drugs that can inhibit this process and thereby slow the growth of tumors.

See Also

• Angiogenesis
• Sprouting angiogenesis
• Vascular endothelial growth factor
• Angiopoietin