Iodine I 131 tositumomab
Iodine I 131 Tositumomab
Iodine I 131 tositumomab is a radioimmunotherapy treatment used primarily for certain types of non-Hodgkin lymphoma. It combines a monoclonal antibody, tositumomab, with a radioactive isotope, iodine-131, to target and destroy cancerous B cells.
Mechanism of Action[edit | edit source]
Iodine I 131 tositumomab works by targeting the CD20 antigen, a protein found on the surface of B cells, including those that are cancerous in non-Hodgkin lymphoma. The monoclonal antibody tositumomab binds to the CD20 antigen, and the attached radioactive iodine-131 delivers targeted radiation to the cancer cells, leading to their destruction.
Administration[edit | edit source]
The treatment is administered in two steps:
1.Dosimetric Dose: Initially, a dosimetric dose of tositumomab followed by iodine I 131 tositumomab is given to determine the appropriate therapeutic dose. This step helps in calculating the radiation dose that will be delivered to the patient.
2.Therapeutic Dose: After the dosimetric dose, the therapeutic dose is administered. This involves a higher dose of iodine I 131 tositumomab to effectively treat the lymphoma.
Indications[edit | edit source]
Iodine I 131 tositumomab is indicated for the treatment of patients with CD20-positive, follicular non-Hodgkin lymphoma, particularly in cases where the disease is refractory to conventional chemotherapy or has relapsed.
Side Effects[edit | edit source]
Common side effects of iodine I 131 tositumomab include:
-Hematologic Toxicity: Patients may experience low blood cell counts, including neutropenia, thrombocytopenia, and anemia. -Infusion Reactions: Some patients may have allergic reactions during the infusion, such as fever, chills, or rash. -Radiation Exposure: As a radioactive treatment, there is a risk of radiation exposure to the patient and others.
Precautions[edit | edit source]
Patients receiving iodine I 131 tositumomab should be monitored for hematologic toxicity and potential radiation exposure. It is important to follow safety guidelines to minimize radiation exposure to family members and healthcare providers.
Also see[edit | edit source]
- Radioimmunotherapy - Monoclonal antibody therapy - Non-Hodgkin lymphoma - Iodine-131 - CD20
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