Irofulven
Irofulven (also known as 6-hydroxymethylacylfulvene) is a semisynthetic derivative of illudin S, a natural product from the Jack O'Lantern mushroom (Omphalotus illudens). It is an alkylating agent used in cancer treatment.
History[edit | edit source]
Irofulven was developed by the pharmaceutical company MGI Pharma, which was later acquired by Eisai. The drug was derived from a natural product, illudin S, which is found in the Jack O'Lantern mushroom.
Mechanism of action[edit | edit source]
Irofulven induces apoptosis in cancer cells by causing DNA damage. It forms covalent adducts with DNA, which leads to the formation of DNA double-strand breaks. This triggers the cell cycle checkpoint machinery and leads to cell death.
Clinical trials[edit | edit source]
Irofulven has been tested in several clinical trials for various types of cancer, including prostate cancer, ovarian cancer, and pancreatic cancer. However, it has not yet been approved by the Food and Drug Administration (FDA) for any indication.
Side effects[edit | edit source]
The most common side effects of irofulven are nausea, vomiting, fatigue, and anemia. Other side effects can include neutropenia, thrombocytopenia, and alopecia.
See also[edit | edit source]
References[edit | edit source]
| Irofulven Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
