Islatravir
Islatravir (also known as MK-8591 or EFdA) is an experimental antiretroviral medication in development by Merck & Co. for the treatment and prevention of HIV/AIDS. It is a nucleoside reverse transcriptase translocation inhibitor (NRTTI).
Mechanism of action[edit | edit source]
Islatravir is a nucleoside reverse transcriptase translocation inhibitor (NRTTI). It works by inhibiting the reverse transcriptase enzyme, an essential protein for the replication of HIV. Unlike other nucleoside reverse transcriptase inhibitors (NRTIs), islatravir causes the DNA chain to pause, rather than immediately terminate, allowing it to bind more tightly to the reverse transcriptase enzyme.
Development and clinical trials[edit | edit source]
Islatravir is currently in phase II/III clinical trials for both the treatment and prevention of HIV/AIDS. Early results from these trials have shown promise, with islatravir demonstrating potent antiretroviral activity and a good safety profile.
Potential advantages[edit | edit source]
Islatravir has several potential advantages over existing antiretroviral medications. It has a long half-life, which could allow for less frequent dosing. It also has a high barrier to resistance, meaning it could be effective in patients who have developed resistance to other antiretroviral medications.
See also[edit | edit source]
| Islatravir Resources | ||
|---|---|---|
|
| |
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD
