Isoaminile
Isoaminile is a cough suppressant and analgesic that was previously used in over-the-counter (OTC) medications. It is a member of the ethylmorphine class of drugs, which also includes codeine and dihydrocodeine. Isoaminile was withdrawn from the market due to concerns about its potential for abuse and addiction.
History[edit]
Isoaminile was first synthesized in the 1950s as a potential alternative to codeine. It was marketed under the brand name Pertofrane by the French pharmaceutical company Rhône-Poulenc. However, it was later withdrawn from the market due to concerns about its potential for abuse and addiction.
Pharmacology[edit]
Isoaminile acts as a mu-opioid receptor agonist, similar to other drugs in the ethylmorphine class. This means it binds to and activates the mu-opioid receptors in the brain, which are responsible for mediating the effects of opioids. This results in a reduction in cough reflex and pain sensation.
Side Effects[edit]
The side effects of Isoaminile are similar to those of other opioids and can include drowsiness, nausea, constipation, and respiratory depression. In addition, long-term use can lead to physical dependence and withdrawal symptoms upon cessation.
Legal Status[edit]
Isoaminile is currently a Schedule II controlled substance in the United States, meaning it has a high potential for abuse and its use is severely restricted. It is also controlled under similar laws in many other countries.
See Also[edit]
