Isoaminile

Isoaminile

Isoaminile is a cough suppressant and analgesic that was previously used in over-the-counter (OTC) medications. It is a member of the ethylmorphine class of drugs, which also includes codeine and dihydrocodeine. Isoaminile was withdrawn from the market due to concerns about its potential for abuse and addiction.

History

Isoaminile was first synthesized in the 1950s as a potential alternative to codeine. It was marketed under the brand name Pertofrane by the French pharmaceutical company Rhône-Poulenc. However, it was later withdrawn from the market due to concerns about its potential for abuse and addiction.

Pharmacology

Isoaminile acts as a mu-opioid receptor agonist, similar to other drugs in the ethylmorphine class. This means it binds to and activates the mu-opioid receptors in the brain, which are responsible for mediating the effects of opioids. This results in a reduction in cough reflex and pain sensation.

Side Effects

The side effects of Isoaminile are similar to those of other opioids and can include drowsiness, nausea, constipation, and respiratory depression. In addition, long-term use can lead to physical dependence and withdrawal symptoms upon cessation.

Legal Status

Isoaminile is currently a Schedule II controlled substance in the United States, meaning it has a high potential for abuse and its use is severely restricted. It is also controlled under similar laws in many other countries.

See Also

• Ethylmorphine
• Codeine
• Dihydrocodeine
• Mu-opioid receptor

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