Epiandrosterone

From WikiMD's Wellness Encyclopedia

(Redirected from Isoandrosterone)

Epiandrosterone, also known as 3β-androsterone, 3β-hydroxy-5α-androstan-17-one, or 5α-androstan-3β-ol-17-one, is an endogenous steroid hormone and a weak androgen with a minor role in the body's androgen physiology. It is a metabolite of the most abundant adrenal androgens, dehydroepiandrosterone (DHEA) and androstenedione, and to a lesser extent, of testosterone. Epiandrosterone is also produced in the brain where it functions as a neurosteroid.

Biosynthesis and Metabolism[edit | edit source]

Epiandrosterone is synthesized from DHEA (dehydroepiandrosterone) through the action of the enzyme 3β-hydroxysteroid dehydrogenase. This conversion occurs in various tissues, including the liver, skin, and brain. The metabolic pathways of epiandrosterone involve its conversion back to DHEA, reduction to dihydrotestosterone (DHT) via 5α-reductase, or aromatization to estrogens. Its presence in the body is thus part of a complex interplay of hormonal regulation and conversion.

Function[edit | edit source]

As a neurosteroid, epiandrosterone is involved in the modulation of neuronal excitability and the regulation of various brain functions, including mood and cognition. Despite being a weak androgen, it can still bind to and activate androgen receptors, albeit with much lower affinity than testosterone or DHT. Its role in the peripheral body is less significant, but it may contribute to the androgenic effects in tissues where it is locally synthesized.

Clinical Significance[edit | edit source]

Epiandrosterone has been studied for its potential in medical applications, including its effects on energy, mood, and overall well-being. However, its weak androgenic activity makes it a less prominent target for therapeutic interventions compared to other androgens. In sports and bodybuilding, epiandrosterone supplements are sometimes used for their potential to increase strength and muscle mass, although the efficacy and safety of such practices are not well-established.

Pharmacology[edit | edit source]

Epiandrosterone is available as a dietary supplement, often marketed for its supposed benefits in enhancing physical performance and body composition. However, the scientific evidence supporting these claims is limited. As with other androgens and steroid supplements, the use of epiandrosterone can have side effects and interactions with other medications, highlighting the need for caution and medical supervision when considering its use.

Research[edit | edit source]

Research on epiandrosterone is ongoing, with studies exploring its potential roles in health and disease. Investigations into its effects on neuroprotection, metabolism, and the immune system suggest that epiandrosterone may have broader physiological implications than previously understood. However, more research is needed to fully elucidate its functions and therapeutic potential.


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD