Isomerase

Isomerase is a type of enzyme that catalyzes the structural rearrangement of isomers. Isomerases thus enhance the chemical reaction rate by facilitating the conversion of molecules into their isomers. This process is crucial in various biological functions, including metabolism and DNA repair.

Types of Isomerases[edit | edit source]

There are six classes of isomerases based on the type of reaction they catalyze:

Epimerase and racemase isomerases: These enzymes catalyze reactions where an inversion of stereochemistry occurs.
Tautomerase: These enzymes catalyze the transfer of protons in the process of tautomerization.
Mutase: These enzymes transfer functional groups from one position to another within a molecule.
Cis-trans isomerase: These enzymes catalyze the interconversion of cis and trans isomers.
Intramolecular transferase: These enzymes transfer groups within a molecule to yield isomeric forms.

Function[edit | edit source]

Isomerases play a crucial role in the cellular metabolism by facilitating the interconversion of molecules into their isomers. This process is essential for the proper functioning of biological systems. For instance, the enzyme phosphohexose isomerase is involved in the glycolysis pathway, converting glucose-6-phosphate into fructose-6-phosphate.

Clinical Significance[edit | edit source]

Isomerases have significant clinical implications. For example, the deficiency of the enzyme glucose-6-phosphate isomerase can lead to hemolytic anemia. Moreover, isomerases are potential targets for drug development in the treatment of diseases such as cancer and infectious diseases.

See Also[edit | edit source]

Isomerase Resources
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