Isopregnanolone

From WikiMD's Wellnesspedia

Isopregnanolone, also known as 3α-hydroxy-5β-pregnan-20-one or 3α,5β-tetrahydroprogesterone, is a neurosteroid that is produced in the brain and adrenal gland. It is a metabolite of progesterone and allopregnanolone.

Chemistry[edit | edit source]

Isopregnanolone is a pregnanolone, which is a type of neurosteroid. It is also a ketone and a hydroxysteroid. The chemical formula for isopregnanolone is C21H34O2.

Biosynthesis[edit | edit source]

Isopregnanolone is produced in the body from progesterone through the action of the enzyme 5α-reductase. It is further metabolized to allopregnanolone by the enzyme 3α-hydroxysteroid dehydrogenase.

Pharmacology[edit | edit source]

Isopregnanolone has been found to have neuroprotective effects. It is thought to act by modulating the GABA receptor in the brain.

Research[edit | edit source]

Research has suggested that isopregnanolone may have potential therapeutic uses in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. However, more research is needed to confirm these findings.

See also[edit | edit source]


Isopregnanolone Resources

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Contributors: Prab R. Tumpati, MD