JAK1

JAK1 or Janus kinase 1 is a human gene that encodes a member of the Janus kinase (JAK) family of tyrosine kinases. These proteins are involved in the transduction of intracellular signals from cytokines and growth factors. The encoded protein is a key regulator of numerous immune functions.

Function

The protein encoded by the JAK1 gene is a member of the Janus kinase (JAK) family of tyrosine kinases. These proteins are involved in the transduction of intracellular signals from cytokines and growth factors. The encoded protein is a key regulator of numerous immune functions. It is involved in the JAK-STAT signaling pathway, which is a critical component of the immune response.

Clinical significance

Mutations in the JAK1 gene have been associated with various diseases, including cancer, autoimmune diseases, and inflammatory diseases. In particular, JAK1 has been implicated in the pathogenesis of rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Inhibitors

Several JAK inhibitors have been developed for the treatment of various diseases. These drugs work by blocking the activity of JAK1 and other members of the JAK family, thereby reducing inflammation and other symptoms.

See also

• Janus kinase
• JAK-STAT signaling pathway
• JAK inhibitors

References

JAK1 Resources
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