JAK3

JAK3 or Janus kinase 3 is a protein that in humans is encoded by the JAK3 gene. It is a member of the Janus kinase family and has a role in the signaling process of various cytokines.

Function

JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which are involved in the signaling process of various cytokines. The activation of JAK3 is associated with the transduction of signals for the growth and differentiation of hematopoietic cells.

Clinical significance

Mutations in the JAK3 gene are associated with autosomal severe combined immunodeficiency (SCID), a disorder characterized by the absence of both T and B lymphocytes.

See also

• Janus kinase
• Severe combined immunodeficiency
• Tyrosine kinase

External links

• JAK3 at the US National Library of Medicine Medical Subject Headings (MeSH)

JAK3 Resources
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