JARID1B

JARID1B, also known as KDM5B or PLU-1, is a gene that encodes a protein in humans. This protein is a member of the Jumonji/ARID domain-containing family, which is involved in the regulation of gene expression.

Function

The JARID1B protein is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It preferentially demethylates tri- and di-methylated lysine 4, which are associated with gene activation. By demethylating lysine 4, it plays a role in the repression of gene transcription. It is also involved in the cell cycle progression and cell differentiation, contributing to the maintenance of stem cell properties.

Clinical Significance

JARID1B is overexpressed in many types of cancer, including breast cancer, prostate cancer, and melanoma. Its overexpression is associated with increased cell proliferation, invasion, and metastasis. Therefore, JARID1B is considered a potential therapeutic target for these cancers.

Research

Research on JARID1B is ongoing, with studies focusing on its role in cancer progression and potential as a therapeutic target. In addition, research is being conducted to understand the mechanisms by which JARID1B regulates gene expression and contributes to stem cell properties.

See Also

• Histone demethylase
• Gene expression
• Cell cycle
• Stem cell