JARID1B

From WikiMD's Wellness Encyclopedia

JARID1B, also known as KDM5B or PLU-1, is a gene that encodes a protein in humans. This protein is a member of the Jumonji/ARID domain-containing family, which is involved in the regulation of gene expression.

Function[edit | edit source]

The JARID1B protein is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It preferentially demethylates tri- and di-methylated lysine 4, which are associated with gene activation. By demethylating lysine 4, it plays a role in the repression of gene transcription. It is also involved in the cell cycle progression and cell differentiation, contributing to the maintenance of stem cell properties.

Clinical Significance[edit | edit source]

JARID1B is overexpressed in many types of cancer, including breast cancer, prostate cancer, and melanoma. Its overexpression is associated with increased cell proliferation, invasion, and metastasis. Therefore, JARID1B is considered a potential therapeutic target for these cancers.

Research[edit | edit source]

Research on JARID1B is ongoing, with studies focusing on its role in cancer progression and potential as a therapeutic target. In addition, research is being conducted to understand the mechanisms by which JARID1B regulates gene expression and contributes to stem cell properties.

See Also[edit | edit source]

References[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD