JDTic
JDTic is a research chemical which is used in scientific studies. It acts as a selective antagonist for the κ-opioid receptor, and has been used to develop a variety of derivatives with improved potency and selectivity.
Chemistry[edit | edit source]
JDTic is a derivative of the opioid antagonist norbinaltorphimine. It is structurally similar to other κ-opioid receptor antagonists such as norbinaltorphimine and 5'-GNTI, but has a different substitution pattern on the tetrahydroisoquinoline ring, which results in significantly increased potency and selectivity for the κ-opioid receptor.
Pharmacology[edit | edit source]
JDTic acts as a selective antagonist for the κ-opioid receptor, with a Ki value of 0.006 nM, making it one of the most potent κ-opioid receptor antagonists known. It has been shown to block the effects of κ-opioid receptor agonists in animal studies, and has been used to develop a variety of derivatives with improved potency and selectivity.
Research[edit | edit source]
JDTic has been used in scientific research to study the role of the κ-opioid receptor in various physiological and pathological processes. It has been used to investigate the role of the κ-opioid receptor in pain, depression, anxiety, addiction, and other conditions.
See also[edit | edit source]
References[edit | edit source]
| JDTic Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
