JTV-519
JTV-519[edit | edit source]
JTV-519, also known as K201, is a pharmaceutical compound that acts as a calcium channel modulator. It is primarily studied for its potential therapeutic effects in treating cardiac arrhythmias and heart failure. JTV-519 belongs to a class of drugs known as ryanodine receptor stabilizers, which are involved in the regulation of intracellular calcium levels in cardiac muscle cells.
Mechanism of Action[edit | edit source]
JTV-519 exerts its effects by stabilizing the ryanodine receptor (RyR2) on the sarcoplasmic reticulum of cardiac myocytes. The ryanodine receptor is a crucial component in the process of excitation-contraction coupling in cardiac muscle. By stabilizing this receptor, JTV-519 helps to prevent abnormal calcium leakage from the sarcoplasmic reticulum, which can lead to cardiac arrhythmias.
Clinical Applications[edit | edit source]
JTV-519 has been investigated for its potential use in treating various cardiac conditions, including:
The drug's ability to modulate calcium handling in cardiac cells makes it a promising candidate for managing these conditions, which are often characterized by disrupted calcium homeostasis.
Pharmacokinetics[edit | edit source]
The pharmacokinetic profile of JTV-519 includes its absorption, distribution, metabolism, and excretion. It is important to understand these parameters to optimize its therapeutic use and minimize potential side effects.
Research and Development[edit | edit source]
Ongoing research is focused on further elucidating the precise mechanisms by which JTV-519 stabilizes the ryanodine receptor and its long-term effects on cardiac function. Studies are also exploring its potential benefits in other calcium-related disorders beyond cardiac diseases.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
