JWH-150

JWH-150.svg

JWH-150 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist for the cannabinoid receptors, specifically the CB1 and CB2 receptors. JWH-150 was developed by Dr. John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-150 has the chemical formula C24H23NO and a molecular weight of 341.45 g/mol. It is structurally related to other compounds in the JWH series, such as JWH-018 and JWH-073. The compound features a naphthoyl group attached to an indole core, which is a common structural motif among synthetic cannabinoids.

Pharmacology

JWH-150 functions as a full agonist at both the CB1 and CB2 receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite. The binding affinity of JWH-150 to these receptors is similar to that of other synthetic cannabinoids, making it a subject of interest in both medical research and recreational use.

Legal Status

The legal status of JWH-150 varies by country. In many jurisdictions, it is classified as a controlled substance due to its psychoactive effects and potential for abuse. For example, in the United States, JWH-150 is listed as a Schedule I controlled substance under the Controlled Substances Act.

Research and Applications

JWH-150 has been used in scientific research to study the endocannabinoid system and to develop new therapeutic agents. Its high affinity for cannabinoid receptors makes it a useful tool for understanding receptor function and for the development of new drugs targeting these pathways.

Safety and Toxicity

The safety profile of JWH-150 is not well-documented, but like other synthetic cannabinoids, it may pose significant health risks. Adverse effects can include tachycardia, hypertension, hallucinations, and psychosis. Long-term use may lead to dependence and withdrawal symptoms.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• JWH-073
• John W. Huffman