JWH-367

JWH-367

0JWH-367 is a synthetic cannabinoid from the naphthoylindole family. It acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with a binding affinity of 9.0 nM at CB₁ and 2.94 nM at CB₂. JWH-367 is one of the most potent compounds in the series, with a high selectivity for CB₂.

Chemistry

JWH-367 is a member of the JWH series, a group of synthetic cannabinoids named after the initials of their creator, John W. Huffman. The chemical structure of JWH-367 is characterized by a naphthoyl group, a 3-carbon alkyl chain, a cyclic core, and an indole group. The naphthoyl group is attached to the indole group at the 3-position, and the alkyl chain is attached to the nitrogen atom of the indole group.

Pharmacology

JWH-367 acts as a full agonist at the CB1 receptor and the CB2 receptor, two types of cannabinoid receptors in the body that are part of the endocannabinoid system. The binding affinity of JWH-367 is 9.0 nM at CB1 and 2.94 nM at CB2, making it one of the most potent compounds in the JWH series. The high selectivity of JWH-367 for CB2 suggests potential therapeutic applications in conditions where activation of this receptor is beneficial.

Legal Status

The legal status of JWH-367 varies by country. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to other synthetic cannabinoids, which are often associated with illicit drug use. However, the specific legal status of JWH-367 should be verified in each jurisdiction.

See Also

• JWH-018
• JWH-073
• JWH-200
• Synthetic cannabinoids
• Cannabinoid receptor