JWH-372

JWH-372

0JWH-372 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent and selective full agonist for the CB2 receptor, with a Ki of 2.9 nM and a selectivity of 200 times over CB1 receptor.

Chemistry

JWH-372 is part of the JWH series of synthetic cannabinoids, named after the scientist John W. Huffman who first synthesized them. The compound is a naphthoylindole, meaning it has a core indole structure with a naphthoyl group attached. This structure is common to many synthetic cannabinoids, which often vary in the specific substitutions made to the indole ring.

Pharmacology

JWH-372 acts as a full agonist at the CB2 receptor, meaning it fully activates the receptor when it binds. Its Ki, or binding affinity, is 2.9 nM, indicating a high degree of binding to the receptor. It has a selectivity of 200 times over the CB1 receptor, meaning it is much more likely to bind to and activate the CB2 receptor.

Effects

The effects of JWH-372 are not well-studied, but as a synthetic cannabinoid, it is likely to produce effects similar to those of cannabis, including relaxation, altered perception, and potentially, pain relief. However, due to its selectivity for the CB2 receptor, it may have different effects than cannabinoids that bind more evenly to both CB1 and CB2 receptors.

Legal Status

The legal status of JWH-372 varies by country and region. In many places, it is considered a controlled substance due to its similarity to cannabis. However, as a research chemical, it may be legal in some jurisdictions for research purposes.

See Also

• JWH-018
• JWH-073
• JWH-200
• Synthetic cannabinoids
• Cannabinoid receptor

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