KCND2

KCND2 is a gene that encodes a protein known as potassium voltage-gated channel subfamily D member 2. This protein is part of the voltage-gated potassium channel family, which plays a crucial role in the electrical excitability of neurons and cardiac myocytes.

Function

The KCND2 gene product is involved in the formation of the transient outward potassium current (I_to), which is important for the repolarization phase of the action potential in neurons and cardiac cells. This current helps to regulate the duration of the action potential and the frequency of neuronal firing.

Clinical Significance

Mutations or dysregulation of the KCND2 gene can lead to various neurological disorders and cardiac arrhythmias. Research has shown that alterations in KCND2 expression or function may be associated with conditions such as epilepsy, ataxia, and Brugada syndrome.

Expression

KCND2 is predominantly expressed in the central nervous system, particularly in the cerebral cortex, hippocampus, and cerebellum. It is also expressed in the heart, where it contributes to the cardiac action potential.

Interactions

KCND2 interacts with several auxiliary subunits and proteins that modulate its function. These include KChIP proteins, which enhance the surface expression and stability of the channel, and DPP6 and DPP10, which modulate the kinetics and voltage dependence of the channel.

See Also

• Voltage-gated potassium channel
• Action potential
• Neuronal excitability
• Cardiac electrophysiology

External Links

• KCND2 Gene - NCBI
• KCND2 Gene - GeneCards