KCND2

KCND2 is a gene that encodes the protein Kv4.2 in humans. Kv4.2 is a voltage-gated potassium channel that plays a crucial role in the regulation of neuronal excitability, particularly in the brain. The KCND2 gene is located on chromosome 7.

Function

The protein Kv4.2, encoded by the KCND2 gene, is a member of the potassium channel, voltage-gated, shal-related subfamily. These channels are known to significantly influence the properties of neuronal action potentials. Kv4.2 channels are primarily responsible for the A-type current in neurons, a rapidly inactivating current that helps to regulate the frequency of action potentials.

Clinical Significance

Mutations in the KCND2 gene have been associated with various neurological disorders. For instance, a mutation in this gene has been linked to epilepsy, a neurological disorder characterized by recurrent seizures. Additionally, alterations in the expression of the KCND2 gene have been implicated in the pathogenesis of schizophrenia and bipolar disorder.

Research

Research into the KCND2 gene and its encoded protein, Kv4.2, is ongoing. Understanding the precise role of this gene in neuronal function and in various neurological disorders could potentially lead to the development of new therapeutic strategies.

File:KCND2 gene location on human chromosome 7.png

Location of the KCND2 gene on human chromosome 7.

See Also

• Voltage-gated potassium channel
• Action potential
• Neuron
• Epilepsy
• Schizophrenia
• Bipolar disorder

References

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