Kir2.1

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

(Redirected from KCNJ2)

Kir2.1 is a protein that in humans is encoded by the KCNJ2 gene. It is a member of the inward-rectifier potassium channel family and is predominantly expressed in the heart and neurons.

Function[edit | edit source]

Kir2.1 is a strong inward rectifier K+ channel. The inward rectification is mainly due to the blockage of outward current by internal Mg2+ and polyamines. This channel is a major contributor to the native inward rectifying K+ current in heart and neurons.

Clinical significance[edit | edit source]

Mutations in the KCNJ2 gene are associated with Andersen-Tawil syndrome, a rare disorder that affects the heart, facial features, and muscle movement. This condition is characterized by a triad of distinctive features: periodic paralysis, heart rhythm abnormalities (arrhythmias), and developmental abnormalities.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

WHO Rod.svg
This article is a medical stub. You can help WikiMD by expanding it!
PubMed
Wikipedia


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP1 injections in NYC from $125 and up biweekly

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.

Why choose W8MD?

Book Your Appointment

Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD