KCNK15

KCNK15 is a human gene that encodes for the protein known as potassium channel subfamily K member 15. This protein is a member of the potassium channel family, which are integral membrane proteins that facilitate potassium ion flow across cell membranes.

Function

The KCNK15 gene is part of a larger group of genes known as the two-pore domain potassium channel (K2P) family. These channels play a critical role in maintaining the resting membrane potential in neurons and muscle cells. The KCNK15 protein is thought to contribute to the regulation of neuronal excitability by contributing to the 'leak' current that helps to set the resting membrane potential.

Clinical significance

Mutations in the KCNK15 gene have been associated with a variety of medical conditions. For example, some studies have suggested a link between KCNK15 mutations and hearing loss. Other research has indicated that KCNK15 may play a role in the development of certain types of cancer, including breast cancer and colorectal cancer. However, more research is needed to fully understand the role of KCNK15 in these conditions.

See also

• Potassium channel
• Two-pore domain potassium channel
• Neuronal excitability
• Hearing loss
• Cancer