KCNK4

KCNK4 also known as Potassium Channel, Two Pore Domain Subfamily K, Member 4 is a protein that in humans is encoded by the KCNK4 gene. It is a member of the potassium channel family of proteins, which are integral membrane proteins that establish a voltage gradient across the membrane, allowing for the selective transport of potassium ions.

Function

KCNK4 is a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to changes in pH and has a function in renal tubular acidosis.

Structure

The KCNK4 protein is a member of the two-pore-domain potassium channel (K2P) family, which is characterized by four transmembrane segments and two pore-forming P domains. The protein structure allows it to form a dimer, with each subunit contributing to the pore region that allows the selective passage of potassium ions.

Clinical Significance

Mutations in the KCNK4 gene have been associated with certain types of renal tubular acidosis, a group of disorders characterized by an imbalance in the body's acid-base balance. Further research is needed to fully understand the role of KCNK4 in disease.

See Also

• Potassium channel
• Renal tubular acidosis

External Links

• GeneCards - KCNK4