KCNN2

KCNN2 is a gene that encodes the protein known as small conductance calcium-activated potassium channel protein 2. This protein is a part of the potassium channel family, which are integral membrane proteins and are essential to the normal functioning of cells.

Function

The KCNN2 protein is a calcium-activated potassium channel that contributes to the regulation of the electrical activity of cells. It is involved in various physiological processes, including the regulation of membrane potential, the modulation of calcium signaling, and the control of cell volume.

Structure

The KCNN2 gene is located on the short (p) arm of chromosome 5 at position 13.3. The protein encoded by this gene has six transmembrane domains and a calcium-activated potassium channel domain.

Clinical significance

Mutations in the KCNN2 gene have been associated with various medical conditions. For example, they have been linked to idiopathic generalized epilepsy, a neurological disorder characterized by recurrent seizures.

Research

Research into the KCNN2 gene and its encoded protein is ongoing. Studies have suggested that the protein may play a role in the development of certain types of cancer, including breast cancer and colorectal cancer.

See also

• Potassium channel
• Calcium signaling
• Membrane potential
• Cell volume
• Chromosome 5
• Idiopathic generalized epilepsy
• Cancer