KHDRBS3

KHDRBS3 (KH Domain Containing, RNA Binding, Signal Transduction Associated 3) is a protein that in humans is encoded by the KHDRBS3 gene. This protein is part of a larger family of KHDRBS proteins, which are involved in various cellular processes such as RNA binding and signal transduction. KHDRBS3, in particular, has been studied for its role in cellular differentiation and development, as well as its potential involvement in disease processes, including certain forms of cancer.

Function

KHDRBS3 is known to play a role in the regulation of gene expression at the post-transcriptional level. It achieves this through its ability to bind to RNA, thereby influencing the stability and translation of messenger RNAs (mRNAs). The specific RNA-binding activity of KHDRBS3 is mediated by its KH domain, a common feature among the KHDRBS family members. This domain allows KHDRBS3 to interact with specific RNA sequences, affecting the fate of the bound RNAs and thus regulating the expression of genes involved in various cellular functions.

Clinical Significance

Research has suggested that KHDRBS3 may have implications in the development and progression of certain diseases. Its role in cellular differentiation makes it a protein of interest in cancer research, where aberrant differentiation processes are a hallmark. Some studies have indicated that altered expression levels of KHDRBS3 are associated with various types of cancer, although the exact mechanisms and implications of these associations remain under investigation. Furthermore, due to its involvement in RNA binding and signal transduction, KHDRBS3 is also being studied in the context of other diseases that involve disruptions in cellular signaling and gene expression.

See Also

• Protein
• RNA
• Gene expression
• Cancer
• Cellular differentiation