KLF11

KLF11 (Krüppel-like factor 11), also known as TIEG2 (TGF-beta-inducible early growth response protein 2), is a protein that in humans is encoded by the KLF11 gene. It is a member of the Krüppel-like factor family of transcription factors.

Function

KLF11 is a transcription factor that binds directly to specific recognition motifs in the promoters of target genes and regulates their expression in response to physiological signals. The protein has been shown to interact with histone deacetylases and repress the transcription of target genes. It also has anti-proliferative effects and can inhibit the growth of human pancreatic cancer cells.

Clinical significance

Mutations in the KLF11 gene have been associated with Type 2 diabetes and Maturity onset diabetes of the young (MODY). The protein is also implicated in the regulation of serotonin transporter genes and may play a role in mood disorders.

Structure

The KLF11 protein is composed of 598 amino acids and has a molecular weight of approximately 66 kDa. It contains three C2H2-type zinc fingers at the C-terminus, which are responsible for its DNA-binding activity.

Expression

KLF11 is expressed in a variety of tissues, including the pancreas, brain, kidney, and heart. Its expression is regulated by several factors, including TGF-beta and glucose.

Research

Research on KLF11 is ongoing, with studies focusing on its role in diabetes, cancer, and mood disorders. It is also being investigated as a potential therapeutic target for these conditions.

File:KLF11 protein structure.jpg

Structure of the KLF11 protein. Image from Wikimedia Commons.

See also

• Krüppel-like factors
• Transcription factor
• Type 2 diabetes
• Maturity onset diabetes of the young
• Histone deacetylase