KLH

KLH or Keyhole Limpet Hemocyanin is a large, multisubunit, oxygen-carrying, metalloprotein that is found in the hemolymph of the giant keyhole limpet species, Megathura crenulata. It is used extensively in medical research due to its immunogenic properties.

Structure[edit | edit source]

KLH is composed of two distinct subunits, KLH1 and KLH2, which are assembled into didecamers and multidecamers, respectively. The KLH1 subunit has a molecular weight of approximately 350,000 Daltons, while the KLH2 subunit has a molecular weight of approximately 390,000 Daltons. Each subunit contains multiple copper atoms, which are responsible for the protein's oxygen-carrying capabilities.

Uses in Medical Research[edit | edit source]

Due to its large size and complex structure, KLH is highly immunogenic and is often used as a carrier protein in the production of antibodies. It is also used in vaccine development, as it can stimulate a strong immune response. In addition, KLH has been used in the study of neurobiology, as it can induce the production of neuropeptides and other signaling molecules.

Safety and Side Effects[edit | edit source]

While KLH is generally considered safe for use in research, it can cause side effects in some individuals. These can include fever, chills, and allergic reactions. However, these side effects are usually mild and temporary.

See Also[edit | edit source]

KLH Resources
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