KLH
KLH or Keyhole Limpet Hemocyanin is a large, multisubunit, oxygen-carrying, metalloprotein that is found in the hemolymph of the giant keyhole limpet species, Megathura crenulata. It is used extensively in medical research due to its immunogenic properties.
Structure[edit | edit source]
KLH is composed of two distinct subunits, KLH1 and KLH2, which are assembled into didecamers and multidecamers, respectively. The KLH1 subunit has a molecular weight of approximately 350,000 Daltons, while the KLH2 subunit has a molecular weight of approximately 390,000 Daltons. Each subunit contains multiple copper atoms, which are responsible for the protein's oxygen-carrying capabilities.
Uses in Medical Research[edit | edit source]
Due to its large size and complex structure, KLH is highly immunogenic and is often used as a carrier protein in the production of antibodies. It is also used in vaccine development, as it can stimulate a strong immune response. In addition, KLH has been used in the study of neurobiology, as it can induce the production of neuropeptides and other signaling molecules.
Safety and Side Effects[edit | edit source]
While KLH is generally considered safe for use in research, it can cause side effects in some individuals. These can include fever, chills, and allergic reactions. However, these side effects are usually mild and temporary.
See Also[edit | edit source]
| KLH Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
