KLRC2

KLRC2 (Killer Cell Lectin-Like Receptor Subfamily C, Member 2), also known as NKG2C, is a protein that in humans is encoded by the KLRC2 gene. It is a type of receptor found on the surface of natural killer (NK) cells, a type of white blood cell that plays a crucial role in the body's immune system.

Function

The KLRC2 gene provides instructions for making a protein that is found on the surface of NK cells. This protein, known as the NKG2C receptor, helps control the function of these cells. NK cells are a part of the immune system and play a role in the body's defense against infection and cancer. The NKG2C receptor is involved in the activation of NK cells, which allows them to kill infected or cancerous cells in the body.

Structure

The KLRC2 gene is located on the short (p) arm of chromosome 12 at position 13. The gene spans approximately 6,000 base pairs and consists of 6 exons. The NKG2C receptor is a type II transmembrane protein that forms a heterodimer with the CD94 protein. This heterodimer recognizes the non-classical MHC class I molecule, HLA-E.

Clinical significance

Alterations in the KLRC2 gene have been associated with susceptibility to various diseases. For example, a deletion in the KLRC2 gene has been linked to an increased risk of HIV infection. Additionally, variations in this gene have been associated with the progression of hepatitis C virus infection.

See also

• Natural killer cell
• Immune system
• Receptor (biochemistry)
• Chromosome 12