Keratin 13

Keratin 13 (KRT13) is a type of keratin, a group of fibrous structural proteins that are key components in the makeup of the epithelial cells in animals. KRT13 is specifically found in the internal organs and tissues of the body, including the esophagus, tongue, and vagina. It plays a crucial role in maintaining the structural integrity of these tissues.

Structure

Keratin 13 is a type I keratin, which means it is acidic and forms a pair with a type II keratin to create the intermediate filaments in epithelial cells. These filaments are essential for the mechanical stability and resilience of the cells. The gene for KRT13 is located on chromosome 17 in humans.

Function

The primary function of KRT13 is to provide structural support to the epithelial cells in which it is found. It helps these cells withstand physical stress and protects them from damage. In addition, KRT13 is involved in several cellular processes, including cell growth, proliferation, and differentiation.

Clinical significance

Mutations in the KRT13 gene can lead to a variety of medical conditions. For example, a mutation in this gene is responsible for White Sponge Nevus, a rare autosomal dominant condition characterized by white, spongy plaques in the oral mucosa. Research is ongoing to understand the full range of conditions associated with KRT13 mutations.

See also

• Keratin
• Epithelial cells
• White Sponge Nevus