Kindling model
Model for the development of seizures
Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. Although kindling is a widely used model, its applicability to human epilepsy is controversial.
Method[edit | edit source]
The word kindling is a metaphor: the increase in response to small stimuli is similar to the way small burning twigs can produce a large fire.
The brains of experimental animals are repeatedly stimulated, usually with electricity, to induce the seizures.
New approaches[edit | edit source]
In 2019, a new model to develop kindling in neocortex was developed using optogenetics (light) instead of passing electrical current.
See also[edit | edit source]
- Kindling (sedative–hypnotic withdrawal)
- Epileptogenesis
- Racine Stages (a method by which seizure severity is quantified in animal models of epilepsy)
References[edit | edit source]
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