Korsakov's psychosis

Korsakov's Psychosis is a chronic memory disorder caused by severe deficiency of thiamine (vitamin B-1). The most common cause is alcohol misuse, but certain other conditions also can cause the syndrome.

Causes

Korsakov's psychosis, also known as Wernicke-Korsakoff syndrome, is most commonly caused by alcohol misuse. Other conditions such as anorexia, overly stringent dieting, fasting, starvation or weight-loss surgery can also lead to thiamine (vitamin B-1) deficiency, which in turn can cause Korsakov's psychosis.

Symptoms

The symptoms of Korsakov's psychosis can include both physical and mental changes. Physical symptoms can include unsteady gait and lack of coordination, while mental symptoms can include amnesia, confusion, and making things up (confabulation).

Diagnosis

Diagnosis of Korsakov's psychosis is based on the patient's medical and alcohol use history, a physical examination, and sometimes on the results of a neuropsychological test.

Treatment

Treatment for Korsakov's psychosis involves replacing the missing thiamine, stopping alcohol misuse, eating a balanced diet, and taking supplements to boost vitamin levels.

Prognosis

The prognosis for Korsakov's psychosis is generally poor. The disorder is often progressive, leading to disability and requiring long-term care.

See also

• Alcohol and health
• Alcohol-related dementia
• Alcoholism
• Thiamine deficiency