L-838,417
L-838,417 is a sedative and anxiolytic drug in the benzodiazepine class. It has selective effects for GABA receptors in the brain, and has a fast onset of effects and short duration of action. It was developed by a team at Merck & Co. and can be used in scientific research.
Pharmacology[edit | edit source]
L-838,417 is a partial agonist at GABAA receptors. It has a high binding affinity for the alpha 2 and alpha 3 subtypes of GABAA receptors, which are thought to be the subtypes most closely associated with the anxiolytic effects of benzodiazepine drugs. It also has a moderate affinity for the alpha 5 subtype, and a low affinity for the alpha 1 subtype, which is associated with sedation and amnesia.
Uses[edit | edit source]
L-838,417 has been used in scientific research to investigate the role of different GABAA receptor subtypes in the action of benzodiazepine drugs. It has also been used in animal studies to investigate the effects of benzodiazepines on anxiety and other behaviors.
Side Effects[edit | edit source]
As with other benzodiazepines, L-838,417 can cause side effects such as sedation, amnesia, and dependence. However, because it is a partial agonist and has a low affinity for the alpha 1 subtype of GABAA receptors, it may cause fewer side effects than other benzodiazepines.
See Also[edit | edit source]
| L-838,417 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
