LHRH agonist

LHRH agonists or Luteinizing hormone-releasing hormone agonists are a type of medication used primarily in the treatment of prostate cancer and breast cancer. They are also used in the treatment of endometriosis, uterine fibroids, and in assisted reproduction. LHRH agonists work by reducing the production of certain hormones in the body, such as testosterone and estrogen.

Mechanism of action

LHRH agonists work by initially stimulating the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This leads to an increase in the production of sex hormones. However, with continuous use, the pituitary gland becomes desensitized to the drug and eventually stops releasing LH and FSH. This leads to a decrease in the production of sex hormones.

Uses

LHRH agonists are used in the treatment of hormone-responsive cancers such as prostate cancer and breast cancer. They are also used in the treatment of endometriosis and uterine fibroids. In assisted reproduction, LHRH agonists are used to control the timing of ovulation.

Side effects

Common side effects of LHRH agonists include hot flashes, sexual dysfunction, and bone loss. Less common side effects include mood changes, weight gain, and high blood sugar.

Examples

Examples of LHRH agonists include Leuprolide, Goserelin, and Triptorelin.

See also

• LHRH antagonist
• Hormone therapy
• Prostate cancer
• Breast cancer

LHRH agonist Resources
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