LPAR4

LPAR4 or Lysophosphatidic Acid Receptor 4 is a protein that in humans is encoded by the LPAR4 gene. It is a member of the G protein-coupled receptor family and plays a significant role in various biological processes.

Function

LPAR4 is one of the several different receptors for lysophosphatidic acid (LPA), a phospholipid derivative extracellular signaling molecule. LPA receptors influence numerous physiological and pathological processes, including cell proliferation, cell differentiation, and apoptosis.

Gene

The LPAR4 gene is located on the chromosome 19 at position 13.2 and spans approximately 20,000 base pairs. The gene is composed of 2 exons and encodes a 365 amino acid protein.

Clinical Significance

Alterations in LPAR4 have been implicated in several diseases, including cancer, fibrosis, and inflammation. It has been suggested that LPAR4 could be a potential therapeutic target for these diseases.

See Also

• Lysophospholipid receptor
• G protein-coupled receptor
• Lysophosphatidic acid