LRP10
LRP10 is a protein that in humans is encoded by the LRP10 gene. It is a member of the low-density lipoprotein receptor (LDLR) family, which plays a key role in cholesterol metabolism. Mutations in this gene have been associated with various neurodegenerative disorders, including Parkinson's disease and dementia with Lewy bodies.
Function[edit | edit source]
The LRP10 protein is a member of the LDLR family, which is involved in the regulation of lipid metabolism. The protein is thought to play a role in the endocytosis of lipoproteins and other proteins. It is also believed to be involved in the regulation of intracellular cholesterol levels.
Clinical significance[edit | edit source]
Mutations in the LRP10 gene have been associated with several neurodegenerative disorders. These include Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia. The exact mechanism by which these mutations contribute to disease is not fully understood, but it is thought to involve disruption of normal protein trafficking within cells.
See also[edit | edit source]
- Low-density lipoprotein receptor
- Parkinson's disease
- Dementia with Lewy bodies
- Frontotemporal dementia
References[edit | edit source]
External links[edit | edit source]
- LRP10 at the National Center for Biotechnology Information
LRP10 Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD