LRP10
LRP10 is a protein that in humans is encoded by the LRP10 gene. It is a member of the low-density lipoprotein receptor (LDLR) family, which plays a key role in cholesterol metabolism. Mutations in this gene have been associated with various neurodegenerative disorders, including Parkinson's disease and dementia with Lewy bodies.
Function[edit | edit source]
The LRP10 protein is a member of the LDLR family, which is involved in the regulation of lipid metabolism. The protein is thought to play a role in the endocytosis of lipoproteins and other proteins. It is also believed to be involved in the regulation of intracellular cholesterol levels.
Clinical significance[edit | edit source]
Mutations in the LRP10 gene have been associated with several neurodegenerative disorders. These include Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia. The exact mechanism by which these mutations contribute to disease is not fully understood, but it is thought to involve disruption of normal protein trafficking within cells.
See also[edit | edit source]
- Low-density lipoprotein receptor
- Parkinson's disease
- Dementia with Lewy bodies
- Frontotemporal dementia
References[edit | edit source]
External links[edit | edit source]
- LRP10 at the National Center for Biotechnology Information
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Contributors: Prab R. Tumpati, MD
