LRP2

From WikiMD's Wellness Encyclopedia

LRP2 or Low-density lipoprotein receptor-related protein 2 is a protein that in humans is encoded by the LRP2 gene. It is also known as megalin and plays a significant role in the body's metabolism and clearance of lipoproteins and other substances.

Function[edit | edit source]

LRP2 is a member of the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. LRP2 is a large endocytic receptor that is widely expressed and is thought to be involved in lipid metabolism, cell growth and development, and the pathogenesis of Alzheimer's disease.

Clinical significance[edit | edit source]

Mutations in the LRP2 gene have been associated with Donnai-Barrow syndrome and other diseases. Donnai-Barrow syndrome is a rare disorder characterized by agenesis of the corpus callosum, enlarged anterior fontanelle, intellectual disability, and other physical abnormalities.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

  • LRP2 gene on the US National Library of Medicine website
LRP2 Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD