LS-1727

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LS-1727
INN
Drug class Cytostatic antineoplastic agent; Androgen; Anabolic steroid; Androgen ester; Progestogen
Routes of administration Intramuscular injection
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number 54025-36-4
PubChem 320801
DrugBank
ChemSpider 283976
KEGG


LS-1727 (also known as nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate) is a synthetic, injected anabolic–androgenic steroid (AAS) and a nitrosocarbamate ester of nandrolone (19-nortestosterone) which was developed as a cytostatic antineoplastic agent but was never marketed.[1][2][3][4] 

Relative affinities (%) of nandrolone and related steroids
Compound PR 
|| AR

|| ER

|| GR

|| MR

|| SHBG

|| CBG
Nandrolone 
|| 20 || 154–155 || <0.1 || 0.5 || 1.6 || 1–16 || 0.1
Testosterone 
|| 1.0–1.2 || 100 || <0.1 || 0.17 || 0.9 || 19–82 || 3–8
Estradiol 
|| 2.6 || 7.9 || 100 || 0.6 || 0.13 || 8.7–12 || <0.1
Notes: Values are percentages (%). Reference ligands (100%) were progesterone for the PR

, testosterone for the AR , estradiol for the ER , dexamethasone for the GR , aldosterone for the MR , dihydrotestosterone for SHBG , and cortisol for CBG . Sources: See template.

See also[edit | edit source]

References[edit | edit source]

  1. ↑ , Synthesis and evaluation of several new (2-chloroethyl)nitrosocarbamates as potential anticancer agents, J. Med. Chem., 2000, Vol. 43(Issue: 8), pp. 1484–8, DOI: 10.1021/jm990417j, PMID: 10780904,
  2. ↑ {{{last}}}, J. Elks, The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. online version, Springer, ISBN 978-1-4757-2085-3, Pages: 660–,
  3. ↑ , Effect of LS 1727, a nitrosocarbamate of 19-nortestosterone, on the R-3327 rat prostatic adenocarcinoma, Res. Commun. Chem. Pathol. Pharmacol., 1981, Vol. 32(Issue: 2), pp. 309–16, PMID: 7244365,
  4. ↑ , Studies on the mechanism of action of LS 1727, a nitrosocarbamate of 19-nortestosterone, Acta Pharmacol Toxicol (Copenh), 1981, Vol. 48(Issue: 2), pp. 129–38, PMID: 6167141,




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Contributors: Prab R. Tumpati, MD