LS-1727
LS-1727 (also known as nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate) is a synthetic, injected anabolic–androgenic steroid (AAS) and a nitrosocarbamate ester of nandrolone (19-nortestosterone) which was developed as a cytostatic antineoplastic agent but was never marketed.[1][2][3][4]
| Compound | PR
|| AR || ER || GR || MR || SHBG || CBG | ||||||
|---|---|---|---|---|---|---|---|
Nandrolone
|| 20 || 154–155 || <0.1 || 0.5 || 1.6 || 1–16 || 0.1 | |||||||
Testosterone
|| 1.0–1.2 || 100 || <0.1 || 0.17 || 0.9 || 19–82 || 3–8 | |||||||
Estradiol
|| 2.6 || 7.9 || 100 || 0.6 || 0.13 || 8.7–12 || <0.1 | |||||||
| Notes: Values are percentages (%). Reference ligands (100%) were progesterone for the PR
, testosterone for the AR , estradiol for the ER , dexamethasone for the GR , aldosterone for the MR , dihydrotestosterone for SHBG , and cortisol for CBG . Sources: See template. | |||||||
See also[edit | edit source]
References[edit | edit source]
- ↑ , Synthesis and evaluation of several new (2-chloroethyl)nitrosocarbamates as potential anticancer agents, J. Med. Chem., 2000, Vol. 43(Issue: 8), pp. 1484–8, DOI: 10.1021/jm990417j, PMID: 10780904,
- ↑ {{{last}}}, J. Elks, The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. online version, Springer, ISBN 978-1-4757-2085-3, Pages: 660–,
- ↑ , Effect of LS 1727, a nitrosocarbamate of 19-nortestosterone, on the R-3327 rat prostatic adenocarcinoma, Res. Commun. Chem. Pathol. Pharmacol., 1981, Vol. 32(Issue: 2), pp. 309–16, PMID: 7244365,
- ↑ , Studies on the mechanism of action of LS 1727, a nitrosocarbamate of 19-nortestosterone, Acta Pharmacol Toxicol (Copenh), 1981, Vol. 48(Issue: 2), pp. 129–38, PMID: 6167141,
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Contributors: Prab R. Tumpati, MD
