LS-1727
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LS-1727 (also known as nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate) is a synthetic, injected anabolic–androgenic steroid (AAS) and a nitrosocarbamate ester of nandrolone (19-nortestosterone) which was developed as a cytostatic antineoplastic agent but was never marketed.[1][2][3][4]
| Compound | PR | AR | ER | GR | MR | SHBG | CBG |
|---|---|---|---|---|---|---|---|
| Nandrolone | 20 | 154–155 | <0.1 | 0.5 | 1.6 | 1–16 | 0.1 |
| Testosterone | 1.0–1.2 | 100 | <0.1 | 0.17 | 0.9 | 19–82 | 3–8 |
| Estradiol | 2.6 | 7.9 | 100 | 0.6 | 0.13 | 8.7–12 | <0.1 |
| Notes: Values are percentages (%). Reference ligands (100%) were progesterone for the PR
, testosterone for the AR , estradiol for the ER , dexamethasone for the GR , aldosterone for the MR , dihydrotestosterone for SHBG , and cortisol for CBG . Sources: See template. | |||||||
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References[edit | edit source]
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- Abandoned drugs
- Androgens and anabolic steroids
- Antineoplastic drugs
- Estranes
- Hormonal antineoplastic drugs
- Nandrolone esters
- Nitrogen mustards
- Organochlorides
- Prodrugs
- Progestogens
- Chloroethyl compounds
- Nitrosocarbamates
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Contributors: Prab R. Tumpati, MD
