LTBP1
LTBP1 is a protein that in humans is encoded by the LTBP1 gene. It is a member of the latent transforming growth factor beta binding protein (LTBP) family. The LTBP family are extracellular matrix proteins that play a crucial role in the regulation of TGF-beta bioavailability.
Function[edit | edit source]
The LTBP1 gene encodes a member of the latent transforming growth factor beta binding protein (LTBP) family. The encoded protein plays a role in the regulation of TGF-beta bioavailability. The protein interacts with Fibrillin and is thought to be involved in the sequestration of latent TGF-beta complexes in the extracellular matrix.
Clinical significance[edit | edit source]
Mutations in the LTBP1 gene have been associated with Geleophysic dysplasia 2, a rare disorder characterized by short stature, small hands and feet, stiff joints, and thick skin.
Interactions[edit | edit source]
LTBP1 has been shown to interact with:
References[edit | edit source]
External links[edit | edit source]
LTBP1 Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD