Lacidipine

Lacidipine

Lacidipine is a calcium channel blocker that is commonly used in the treatment of hypertension. It is marketed under various trade names, including Motens and Lacipil.

Pharmacology

Lacidipine is a member of the dihydropyridine class of calcium channel blockers, which also includes drugs such as amlodipine and nifedipine. These drugs work by inhibiting the influx of calcium ions into vascular smooth muscle cells, leading to a relaxation of the muscle cells and a reduction in blood pressure.

Clinical Use

Lacidipine is primarily used in the treatment of hypertension, a condition characterized by persistently high blood pressure. It may be used alone or in combination with other antihypertensive drugs. Lacidipine is typically administered orally, and its effects can be seen within a few hours of administration.

Side Effects

Like other calcium channel blockers, lacidipine can cause a range of side effects. These may include dizziness, headache, flushing, and ankle swelling. In rare cases, it can cause more serious side effects such as palpitations, chest pain, and shortness of breath.

Contraindications

Lacidipine is contraindicated in patients with known hypersensitivity to dihydropyridines. It should also be used with caution in patients with severe heart failure, as it can exacerbate the condition.

Interactions

Lacidipine can interact with a number of other drugs, including beta blockers, diuretics, and ACE inhibitors. These interactions can alter the effectiveness of lacidipine and may increase the risk of side effects.

See Also

• Calcium channel blocker
• Hypertension
• Dihydropyridine

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