Lamin A

From WikiMD's Wellness Encyclopedia

Lamin A is a type of protein that in humans is encoded by the LMNA gene. It is a major component of the nuclear lamina, a protein network on the inner edge of the nucleus in a cell. Lamin A is vital for the mechanical stability and integrity of the nucleus, and is involved in a range of nuclear functions including DNA replication and DNA repair.

Structure[edit | edit source]

Lamin A is a type of intermediate filament protein. It has a central rod domain, with a short head and a long tail domain. The central rod domain is made up of four parts, each of which is a coiled coil structure. The head and tail domains are both unstructured and flexible.

Function[edit | edit source]

Lamin A is involved in providing mechanical support to the nucleus, and in organizing and anchoring chromosomes at the nuclear periphery. It also plays a role in DNA replication and repair, and in regulating gene expression.

Clinical significance[edit | edit source]

Mutations in the LMNA gene can lead to a variety of diseases, collectively known as laminopathies. These include Hutchinson-Gilford progeria syndrome, a rare genetic disorder that causes rapid aging in children, and Emery-Dreifuss muscular dystrophy, which affects the muscles and heart.

See also[edit | edit source]

References[edit | edit source]


Lamin A Resources

Contributors: Prab R. Tumpati, MD