Laniquidar
Laniquidar is a pharmacological agent that is primarily used as a P-glycoprotein inhibitor. It is a synthetic compound that has been studied for its potential use in the treatment of multidrug resistance in cancer.
History[edit | edit source]
Laniquidar was first synthesized in the late 20th century as part of a broader effort to develop effective treatments for cancer. The compound was identified as a potent inhibitor of P-glycoprotein, a protein that can contribute to multidrug resistance in cancer cells.
Mechanism of Action[edit | edit source]
Laniquidar functions by inhibiting the activity of P-glycoprotein, a protein that is often overexpressed in cancer cells. P-glycoprotein acts as a pump, expelling anticancer drugs from the cells and thereby reducing their effectiveness. By inhibiting P-glycoprotein, laniquidar can increase the concentration of anticancer drugs within the cells, potentially enhancing their therapeutic effect.
Clinical Trials[edit | edit source]
Several clinical trials have been conducted to evaluate the safety and efficacy of laniquidar. These trials have generally found that laniquidar is well-tolerated and can enhance the effectiveness of certain anticancer drugs. However, further research is needed to fully understand the potential benefits and risks of laniquidar.
Potential Applications[edit | edit source]
In addition to its potential use in cancer treatment, laniquidar may also have applications in other areas of medicine. For example, it has been suggested that laniquidar could be used to enhance the effectiveness of antiviral drugs by inhibiting P-glycoprotein in virus-infected cells.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
