Lapisteride
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Lapisteride is a pharmaceutical compound that functions as a 5-alpha-reductase inhibitor. It is primarily used in the treatment of conditions related to androgens, such as benign prostatic hyperplasia (BPH) and androgenic alopecia.
Mechanism of Action[edit]
Lapisteride works by inhibiting the enzyme 5-alpha-reductase, which is responsible for the conversion of testosterone into dihydrotestosterone (DHT). DHT is a potent androgen that plays a significant role in the development and progression of BPH and androgenic alopecia. By reducing the levels of DHT, Lapisteride helps in alleviating the symptoms associated with these conditions.
Clinical Uses[edit]
Lapisteride is primarily indicated for the treatment of:
- Benign prostatic hyperplasia: It helps in reducing the size of the enlarged prostate, thereby improving urinary flow and reducing the risk of urinary retention.
- Androgenic alopecia: It is used to slow down hair loss and promote hair regrowth in individuals with male pattern baldness.
Side Effects[edit]
Common side effects of Lapisteride include:
- Decreased libido
- Erectile dysfunction
- Ejaculation disorders
These side effects are generally mild and tend to resolve with continued use of the medication.
Pharmacokinetics[edit]
Lapisteride is well absorbed after oral administration. It undergoes extensive hepatic metabolism and is primarily excreted in the urine. The half-life of Lapisteride allows for once-daily dosing, which enhances patient compliance.
Contraindications[edit]
Lapisteride is contraindicated in:
- Women who are or may become pregnant, due to the risk of fetal harm.
- Patients with known hypersensitivity to the drug or any of its components.
