Lasalocid

Lasalocid structure

Lasalocid is an ionophore antibiotic commonly used in veterinary medicine. It is primarily employed as a coccidiostat to prevent and control coccidiosis in poultry and other livestock. Lasalocid is also used as a growth promoter in ruminants, such as cattle and sheep.

Chemical Properties

Lasalocid is a polyether antibiotic that belongs to the class of carboxylic ionophores. It is produced by the fermentation of the bacterium Streptomyces lasaliensis. The compound has a high affinity for binding to cations, particularly sodium and potassium ions, facilitating their transport across biological membranes.

Mechanism of Action

Lasalocid works by disrupting the ion balance within the cells of protozoa and bacteria. By transporting cations across cell membranes, it disrupts the osmotic balance and electrochemical gradient, leading to cell death. This mechanism is particularly effective against Eimeria species, the causative agents of coccidiosis.

Uses in Veterinary Medicine

Lasalocid is widely used in the poultry industry to prevent and control coccidiosis, a disease caused by Eimeria parasites. It is also used in cattle and sheep to improve feed efficiency and promote growth. The compound is often included in feed additives and premixes.

Poultry

In poultry, lasalocid is administered through feed to prevent coccidiosis. It is effective against multiple species of Eimeria, including Eimeria tenella, Eimeria acervulina, and Eimeria maxima. The use of lasalocid helps in maintaining the health and productivity of poultry flocks.

Ruminants

In ruminants, lasalocid is used to improve feed efficiency and promote weight gain. It is often included in the diet of cattle and sheep to enhance growth rates and improve overall health.

Safety and Regulations

Lasalocid is approved for use in many countries, including the United States and the European Union. However, its use is regulated to ensure the safety of both animals and humans. Residue levels in meat and other animal products are monitored to comply with food safety standards.

Related Pages

• Ionophore
• Coccidiosis
• Eimeria
• Feed additive
• Streptomyces lasaliensis

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