Lasalocid

Lasalocid is a polyether ionophore antibiotic that is produced by strains of Streptomyces lasaliensis. It is primarily used in veterinary medicine as a treatment for coccidiosis, a parasitic disease affecting a variety of animals, particularly poultry.

History

Lasalocid was first isolated in 1975 from Streptomyces lasaliensis, a species of actinobacteria known for producing a variety of bioactive compounds. The compound was found to have potent activity against Eimeria species, the parasites responsible for coccidiosis.

Mechanism of Action

Lasalocid functions as an ionophore, a type of compound that can transport ions across cell membranes. Specifically, it forms complexes with monovalent cations, such as sodium and potassium, and facilitates their transport into cells. This disrupts the normal ion balance, leading to the death of the parasite.

Veterinary Use

In veterinary medicine, lasalocid is used primarily to control coccidiosis in poultry. It is also used in cattle to improve feed efficiency and promote weight gain. The compound is typically administered in feed or drinking water.

Human Toxicity

While lasalocid is generally safe for use in animals, it can be toxic to humans if ingested in large amounts. Symptoms of lasalocid poisoning include muscle weakness, nausea, and in severe cases, cardiac arrest.

Regulatory Status

In the United States, lasalocid is approved for use in poultry and cattle by the Food and Drug Administration (FDA). In the European Union, it is approved for use in poultry, but not in cattle.

See Also

• Ionophore
• Coccidiosis
• Streptomyces

• Need help finding a doctor or specialist anywhere in the world? WikiMD's DocFinder can help with millions of doctors!

This article is a stub. Help WikiMD grow by registering to expand it. Editing is available only to registered and verified users. About WikiMD: A comprehensive, free health & wellness encyclopedia.