Latrophilin 3

Latrophilin 3 (LPHN3) is a protein that in humans is encoded by the LPHN3 gene. It is a member of the adhesion G protein-coupled receptor family, which is characterized by a long N-terminal sequence and a seven transmembrane domain.

Function

Latrophilin 3 is a receptor for alpha-latrotoxin, a potent neurotoxin that triggers massive exocytosis from neurons of the central and peripheral nervous systems. This receptor is thought to participate in synaptic transmission and/or synaptogenesis. It is also known to play a role in the process of cell adhesion.

Clinical significance

Mutations in the LPHN3 gene have been associated with attention deficit hyperactivity disorder (ADHD). Studies have shown that individuals with certain variations in the LPHN3 gene have an increased risk of developing ADHD. However, the exact mechanism by which LPHN3 contributes to the development of ADHD is not yet fully understood.

See also

• Adhesion G protein-coupled receptor
• Alpha-latrotoxin
• Attention deficit hyperactivity disorder

External links

• NCBI Gene
• UniProt