Lenomorelin

Lenomorelin (also known as ghrelin) is a peptide hormone produced primarily by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas. It is known as the "hunger hormone" because it stimulates appetite, increases food intake, and promotes fat storage.

Structure and Synthesis

Lenomorelin is a 28-amino acid peptide, with a unique post-translational modification at the third amino acid, a serine residue, which is octanoylated by the enzyme ghrelin O-acyltransferase (GOAT). This modification is necessary for lenomorelin's biological activity.

Function

Lenomorelin functions as a neuropeptide in the central nervous system. Beyond regulating hunger, lenomorelin also plays a significant role in regulating the sleep-wake cycle, reward-seeking behavior, taste sensation and body weight.

Clinical Significance

Lenomorelin has been studied for its potential use in treating growth hormone deficiency and eating disorders. However, its role in disease is not fully understood and is currently the subject of ongoing research.

See Also

• Ghrelin O-acyltransferase
• Growth hormone secretagogue receptor
• Peptide hormone
• Growth hormone deficiency